MATURITY-ONSET DIABETES OF THE YOUNG (MODY): FIRST CASE REPORTED OF GCK-MODY TYPE IN HATTA HOSPITAL, DAHC, UAE
نویسندگان
چکیده
Maturity-onset diabetes of the young (MODY) is a genetically diverse endocrine disorder autosomal dominant inheritance characterized by pancreatic β-cell dysfunction.Since clinical symptoms are so similar, it can be difficult to diagnose MODY accurately, important consider patients family history and any other genetic risk factors when making diagnosis.Glucokinase (GCK) was first gene identified has been associated with defects in several genes.(1)
منابع مشابه
Phenotype Heterogeneity in Glucokinase–Maturity-Onset Diabetes of the Young (GCK-MODY) Patients
OBJECTIVE The aim of the study was to evaluate the clinical phenotypes of glucokinase-maturity-onset diabetes of the young (GCK-MODY) pediatric patients from Southwest Poland and to search for phenotype-genotype correlations. METHODS We conducted a retrospective analysis of data on 37 CGK-MODY patients consisting of 21 girls and 16 boys of ages 1.9-20.1 (mean 12.5±5.2) years, treated in our c...
متن کاملGCK gene mutations are a common cause of childhood‐onset MODY (maturity‐onset diabetes of the young) in Turkey
OBJECTIVE Inactivating heterozygous mutations in the GCK gene are a common cause of MODY and result in mild fasting hyperglycaemia, which does not require treatment. We aimed to identify the frequency, clinical and molecular features of GCK mutations in a Turkish paediatric cohort. DESIGN AND PATIENTS Fifty-four unrelated probands were selected based on the following criteria: age of diagnosi...
متن کامل[Mature onset diabetes of the young (MODY)].
Maturity-onset diabetes of the young (MODY) is a rare form of juvenile diabetes mellitus, defined by early onset, absence of ketosis, non-insulin-dependent diabetes and autosomal dominant inheritance. Advances in molecular genetic analysis have identified mutations accounting for different MODY subtypes, all of them associated with defects of insulin secretion. We present a case of a nine year-...
متن کاملGenetic and clinical characteristics of Chinese children with Glucokinase-maturity-onset diabetes of the young (GCK-MODY)
BACKGROUND There is scarcity of information on the clinical features and genetics of glucokinase-maturity-onset diabetes of the young (GCK-MODY) in China. The aim of the study was to investigate the clinical and molecular characteristics of Chinese children with GCK-MODY. METHODS Eleven children with asymptomatic hyperglycemia and clinically suspected GCK-MODY were identified from the databas...
متن کاملFrequency and genetic spectrum of maturity-onset diabetes of the young (MODY) in southern New Zealand
Maturity-Onset Diabetes of the Young (MODY) is a monogenic form of diabetes, consisting of a heterogeneous group of autosomal dominant inherited disorders. Typical onset is in individuals prior to twenty five years, and presentation can mimic type 1 or 2 diabetes. Molecular genetic testing can allow precise identification of the different MODY sub-types. Making a specific diagnosis of MODY can ...
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ژورنال
عنوان ژورنال: International journal of advanced research
سال: 2023
ISSN: ['2707-7802', '2707-7810']
DOI: https://doi.org/10.21474/ijar01/17153